The Role of Technology in Business Essay Example | Topics and Well Written Essays - 750 words - 2

The Role of Technology in Business - Essay Example Making information available online and reaching prospective consumers via Social Networking can increase the visibility of the products and their qualities. With the increasingly hectic lifestyles of young professionals; marketing online and allowing for sales via the internet makes purchasing convenient and easy, and thus leads to more sales. The consumer populations keep changing as the baton of purchasing power and desire are passed from generation to generation. It is necessary that the industry recognizes the changing needs of the new generation of consumers and make available products and services that compliment the needs of the consumers in such a manner that the products are most visible to the consumer in a positive manner. Knowledge about production and delivery is becoming increasingly common as the connections increase between different parts of the world. Consumers are becoming aware of products that are not local, and are making demands for them; which are quickly met be importing technology and skills. This increases the set of suppliers for any said product or service, increasing the competition for existing organizations. This competition has to be met head-on in order to survive. The busy consumer will prefer to give allegiance to the organization that makes the product and information about it available easily to the consumer. If a consumer is able to get the details s/he requires easily; they are more likely to buy the product. Needs change as the environment of the consumer changes. A product or service that sold well before may not be received well in new circumstances. It is important that the organization is tuned to the pulse of its market and modifies its product/service to suit the needs of its new consumers. Â  

Literature paper #2 Essay Example | Topics and Well Written Essays - 1250 words

Literature paper #2 - Essay Example A sensible reading of the text would reveal Gregors metamorphosis as a metaphor of the modern society where people have become quite alienated, burdened with familial responsibilities and obligations, neurotic, and lack understanding, love, or communion. Twentieth-century modernist images of metamorphosis, on the other hand, lead us to question not only the boundaries of man’s relationship with nature and the supernatural, but the very status of humanity itself, transformed into the monstrous. Gregors metamorphosis is governed by uncontrollable factors that cause both physical and mental changes in his personality. No doubt, Gregors tragedy stems from his strong sense of familial obligation and responsibilities; his subsequent guilt due to his inability to fulfill his responsibilities turns him into a bug and this metamorphosis brings about drastic changes in the gender roles and sibling relations.Gregor’s metamorphosis underlines that man’s existence is absurd a nd meaningless and that human nature is essentially monstrous. His transformation is more inward than physical; it is Kafka’s inner conviction that human nature is inevitably monstrous and meaningless that makes him to depict Grgor’s character as animalistic, and the only possible escape for Gregor is to succumb to the ultimate reality-death. In Metamorphosis, one experiences man’s inner struggle and longing to survive in a world where one cannot find any sort of solace. Everyone seeks his/her existence and is likely to get disillusioned and desperate when things go beyond one’s comprehension and control. Even though the metamorphosis of Gregor sounds to be supernatural and beyond human comprehension, the touching story of Gregor’s misfortunes points to the meaninglessness of human life; man is incapable of fighting the supernatural elements and the essential monstrous human nature that unleashes itself in such turbulent

Annotated Bibliography on Tacrine

Annotated Bibliography on Tacrine Sathyan G et al (1995) studied the effect of solvents such as water, propylene glycol and ethanol and their mixtures for transdermal drug delivery on in vitro permeation of tacrine through rat and human skin. Largest flux and permeability were observed from ethanol-propylene glycol and water-ethanol binary mixtures, respectively. Excellent correlation between the rat and human skin data was observed. The formulations were found to be devoid of skin irritancy property. Ethanol-propylene glycol (1:1) mixture with a flux of 98  µg/cm2 through rat skin was found to be a promising solvent system for the transdermal delivery of Tacrine. Yanq Q et al (2001) formulated microparticles of tacrine using poly (D,L-lactide-co-glycolide) (PLG) by solvent evaporation technique. Effect of formulation variables on Encapsulation efficiency and release was studied. Results showed an increase in encapsulation efficiency by 10 times and decrease in rate of release when molecular weight of polymer was changed from 8,000to 59,000 and 155,000 The study indicated that tacrine microparticles have a strong potential for long term treatment of Alzheimer’s disease. Kankkunen T et al (2002) investigated the iontophoretic delivery of Tacrine on 10 healthy adult volunteers by comparing a commercial LOGEL electrode with an ion exchange fibre formulation. Clinically significant plasma concentrations 21.3+5.9 ng/ml was achieved by commercial system whereas 14.9+2.6 ng/ml was achieved through ion exchange fibre system. The study showed that iontophoretic delivery of Tacrine is safe .Serum alanine transferase levels Jogani VV et al (2008) prepared and characterized mucoadhesive microemulsion of tacrine by the titration method for brain targeting for the treatment of Alzheimer’s disease. Selective nose to brain transport was confirmed by lower Tmax values (60 min) with intranasal administration than 120 min with intravenous administration. The brain bioavailability of tacrine after giving optimized formulation was 2 times more than obtained with intranasal tacrine solution Scintigraphy study in rabbits showed more uptake of Tacrine in brain after intranasal administration. The results indicated better, quicker transport of tacrine in scopolamine-induced amnesic mice brain and rapid regain of memory loss after intranasal administration. Hence, results suggested that intranasal tacrine delivery hold promising in treating Alzheimers disease. Wilson B et al (2010) prepared Tacrine-loaded chitosan nanoparticles by spontaneous emulsification method. The particles were characterized for size, zeta potential, drug-loading capacity and in vitro release. Mean particle size for drug-to-polymer ratio 1:1 was found to be 41  ± 7 nm with average zeta potential of +34.7  ± 1.5 mV. The release of tacrine from nanoparticles ranged from 83.04%  ± 1.41% to 94.64%  ± 0.84% for 12 hours depending on the drug-to-polymer ratio. In vitro release studies showed an initial burst of 30 minutes followed by continuous and slow release of the drug. The release of drug from nanoparticles was diffusion-controlled, following Fickian mechanism. Controlled release characteristics suggested prolonged residence time which could improve the bioavailability of tacrine in the brain. Luppi B et al (2011) prepared albumin nanoparticles of Tacrine hydrochloride with beta cyclodextrin, hydroxypropyl beta cyclodextrin and sulphobutylether beta cyclodextrin using coacervation method and thermal cross-linking. Prepared nanoparticles were then soaked in solutions of tacrine hydrochloride and lyophilized for effective drug loading. Evaluation results showed that nanoparticles had a spherical shape with negative charge and mean size .Dixit S et al (2013) formulated mouth dissolving tablets of Tacrine hydrochloride by direct compression using different superdisintegrants. Results indicated that mouth dissolving tablets showed acceptable hardness, friability, mechanical strength and weight uniformity. The optimized formulation disintegrated in less than 1 minute in mouth and released >98% of Tacrine within 14 minutes. The study reflected the potential of mouth dissolving tablet of Tacrine for quick absorption, improvement in bioavailability, increased patient compliance especially in patients with difficulty in swallowing. Corace G et al (2014) developed liposomes delivery of tacrine hydrochloride by nasal route using cholesterol, phosphatidylcholine, a-tocopherol and/or Omega3 fatty acids by reverse phase evaporation technique followed by membrane filter extrusion. Results reflected that prepare d liposome formulations had a mean diameter varying from 175nm to 219nm with polydispersity index Haughey DB et al(1994) developed a reversed-phase high-performance liquid chromatographic method(RPHPLC) with fluorescence detection for the analysis of Tacrine and 1-hydroxy-, 2-hydroxy-, and 4-hydroxytacrine (metabolites of Tacrine) in human plasma. The alkalinized samples of human plasma were extracted with a mixture of 90:10%v/v of chloroform and l-propanol. Calibration curves were constructed for clinically significant concentrations(5 to 30 ng/ml) for all the analytes. The method was found to be precise and accurate. The developed method was sensitive enough for the determination of tacrine and its metabolites after Cognex (40 mg single dose) was administered orally to normal volunteers. Hansen LL et al (1998) developed and validated a method for simultaneous estimation of tacrine and its metabolites, 1-hydroxytacrine , 2-hydroxytacrine and 4-hydroxytacrine in human plasma and urine .The method involved one-step liquid–liquid extraction with ethyl acetate. Determination was done by isocratic, reversed-phase high-performance liquid chromatography using fluorescence detection (excitation: 330 nm and emission: 365 nm).The developed method demonstrated simplicity , precision, accuracy and sensitivity with limit of detection as 0.5 nM for 2-hydroxytacrine and 4-hydroxytacrine, 2 nM for 1-hydroxytacrine and tacrine in plasma. Mean recovery ranged from 84 to 105% for tacrine and its metabolites in plasma. Aparico I et al (1998) developed a spectrofluorimetric method to estimate tacrine in human serum and pharmaceuticals. The fluorimetric method allowed the determination of Tacrine in the range of 1–70 ng /ml in aqueous solutions of acetic acid–sodium acetate buffer (pH 5.6) with (excitation wavelength of 242 nm and emission wavelength of 362 nm. Chollet DF et al (2000) developed a high-performance liquid chromatography (HPLC) assay method for therapeutic monitoring of Tacrine. The method was based on simple protein precipitation by acetonitrile or cold methanol followed by isocratic separation on a CN column eluted in reversed-phase mode. Developed method was found to be precise, robust, accurate and suitable which was demonstrated by analyzing more than 1,000 plasma samples from patients with Alzheimer disease . Ortuà ±o JA et al (2007) developed a flow-injection pulse amperometric method for estimation of Tacrine on the basis of ion transfer through a plasticized poly(vinyl chloride) (PVC) membrane using a four-electrode potentiostat with ohmic drop compensation. Lnear relationship between peak height and concentration of tacrine was found up to 4Ãâ€"10-5M .Limit of detection was found to be 1Ãâ€"10-7M. The method was found to be linear, reproducible, specific and repeatable. Qian S et al (2012) developed an assay for simultaneous determination of Tacrine and its metabolites in rat plasma and brain tissue. The analytes along with internal standard were extracted from plasma of rat or tissue homogenate of brain by liquid-liquid extraction with the help of ethyl acetate. The separation was done on Thermo Hypersil BDS C18 column using mobile phase of acetonitrile and ammonium formate-triethylamine (pH 4.0) with fluorescence detection. Percentage recovery varied from 82.1% to 93.2% in h rat plasmas and brain tissue. The developed method was found to be simple, sensitive and reproducible procedure for the estimation of Tacrine and its metabolites in rats after oral administration.

Essay on Camus’ The Stranger (The Outsider): Apathy -- Camus Stranger

Apathy in The Stranger (Outsider) Often times an author incorporates a thought or philosophy into a work that can shape or reshape the attitude emitted from the novel. In Albert Camus', The Stranger, the Existential philosophy that the author fills into the work give an aura of apathy. With the opening lines of "Mother died today. Or, maybe, yesterday; I can't be sure," Camus immediately sets a tone of indifference (1). Though the protagonist, Mersault, is not completely without cares, the overall attitude of passiveness he has toward himself, as well as toward others, give the entire novel a tone of apathy. With an analyzation of Mersault's character, an automatic attitude of nonchalance is quickly seen. Mersault does not lie to himself, let alone to others, because he has no need to. He does not care about the set laws of society, and he feels that he has no one to please, including himself, which is a reason why he has no qualms about being brutally honest and not hiding his feelings. This is ...

Indian Burying Grond Essay

The Indian Burying Ground In Freneau’s poem The Indian Burying Ground, the reader is presented with the two different views on life after death. One of the perspectives is from the Christian religion. The other is from the perspective of an Indian religion. The Christian religion thinks that just because you are buried lying down that you will be in an eternal sleep. The Indian religion is just the opposite of this. The religion believes that when you die your soul still lives on and you are reunited with all things that have passed on before you. Through many poetic devices, Freneau contrasts the Indian religion view of life after death and his own. The Indian religion, mentioned in the poem The Indian Burying Ground, and the Christian religion are very different in the belief of an afterlife. The following is from the perspective of Freneau. The lines in the first stanza â€Å"The posture that we give the dead, points out the soul’s eternal sleep.† tells that the lying down posture that Christians are buried in suggests that they will be in an eternal sleep. The Indian religion in the poem says that your soul lives on forever after you die. The second stanza talks about when a person dies he is once again seated with his friends and joins them in a feast. The following quotes from the third stanza â€Å"nature of the soul† and â€Å"knows no rest† suggests that when a person dies the soul of that person doesn’t die with him, but just moves on to another form. In the fourth stanza the quotes â€Å"life is spent† and â€Å"not the old ideas gone† suggests that after you have died your ideas and you as a person are not forgotten but remembered forever. There is a place where all the souls gather and sit. In the fifth stanza there is talk of a stranger observing the place where all the souls have come to sit. This person is obviously influenced by the Christian view of life after death. The person is shown that the souls are not all lying down like he has though but all are in the sitting position. An Indian is showing this person around the place where all the souls have gathered, showing him that people live on after life. One of the things the person is showed is a  tree with kids playing in it’s shade. Another thing he is shown is an ancient Indian queen. There are many other things that man sees to make him believe that what he is seeing is real. People in the world are too closed minded and only put things into reason. It is hard for people to actually believe in what the Indian religion says about life after death because it is too complicated for them to believe in such a thing. When a person is showed to the actual gathering of souls and participating in a feast it is hard for him to deny what is actually happening. A person has no choice but to believe in what is actually occurring. Although the Christian view of an after life differs from the Indian view, the many poetic devices in the poem helps the readers understand the two different perspectives even if they are not normal.

Nuclear Weapons Persuasive Essay Essay

Should every country have the right to possess nuclear weapons? On the 6th November 1945, a United States bomber flew towards the Japanese city of Hiroshima. The only cargo aboard that B-29 bomber was an atomic bomb – ironically nicknamed â€Å"Little Boy† – that was to be dropped on its target. At 8.15am and at a height of around 2,000ft the bomb exploded above Hiroshima, taking 140,000 lives with it. Most of the 140,000 died instantly, horrifyingly the rest of the innocent civilians that were not in direct contact with the bomb died painful deaths in the four months following. They died from radiation sickness and different types of cancers. Whilst the atomic bomb is considered as one of the greatest inventions of all time, in terms of how it could protect a nation, is it really worth having numerous amounts of governments on edge at the thought of a weapon so powerful? Ronald Reagan described nuclear weapons as: â€Å"Totally irrational, totally inhumane, good for nothing but killing, possibly leading to the destruction o f life on Earth and civilisation.† He spoke nothing but the truth. US President Reagan was a nuclear abolitionist. He believed that the only reason to have nuclear weaponry was to prevent the Soviet Union from using theirs. Between them alone the United States and Russia have more than 90% of the world’s nuclear weapons. Why do these countries feel the need to posses so many nuclear warheads? Dominance, power and paranoia. Although some of their weapons may simply just be left over from the Cold War, this is not an excuse. They could have easily been destroyed by now. Countries like Russia and the United States crave power. In modern times the most important substance to guarantee power is weapons. Countries in possession of nuclear weapons use them to scare and intimidate other nations. One day this could backfire and the consequences would be deadly. Take North Korea and America. When Kim-Jong Un tried to invade South Korea, Barack Obama threatened them with an atomic bomb. As soon as that was done North Korea knew they had a major diplomatic issue and rescinded their threat. A major threat to world peace is the potential issue that certain smaller countries are likely to rebel against being manipulated and not having the ability to retaliate. To ensure that they avoid being bullied by bigger powers they may start to produce their own nuclear warheads. As previously stated, the  reason two superpowers like Russia and the United States maintain a significant arsenal of nuclear weaponry is down to the fact that frankly, they are paranoid. If you can stockpile most of the nuclear warheads in the world then surely nobody could ever harm your country. This is certainly not the case. By having so many dangerous weapons you are not only a bigger threat to potential enemies but practically there is the additional threat that Terrorists could pose if they ever managed to secure or steal some of these weapons. Morally we should also be questioning the validity of nuclear weapons, if the leaders of a country say that it is ok to use an extreme sanction like nuclear weapons to threaten enemies then what’s to say that civilians do not do the same thing on a smaller scale? In the beginning of the atomic age atom bombs were created to end the war and to save numerous lives. By this I mean that arguably, multitudinous lives were saved due to the fact that when the bomb was dropped on Hiroshima the Japanese virtually surrendered straight away. If they hadn’t surrendered the war possibly would have gone on for a lot longer. In contrast to this, look at what has become of nuclear weapons now. Instead of saving lives, atomic bombs are now kept with the intention of unnecessary mass murder. What makes the monsters that enforce the use of nuclear weaponry any different from Adolf Hitler, Pol Pot or Joseph Stalin? Even though the atomic bombs are not in use at this moment, anyone or any g overnment in possession of these weapons have the intention to inflict large amounts of pain on vast number of people. Rajiv Gandhi said that the â€Å"nuclear war will not mean the death of one hundred million people. Or even a thousand million. It will mean the extinction of four thousand million: the end of life as we know it on planet earth.† The prospect of a nuclear war is just a horrendous thought, a thought that should never cross our minds. Recently, President Barack Obama and Prime Minister Dmitry Medvedev signed a treaty saying that both countries are willing to reduce their amount of nuclear weapons by one third. It is comforting to see that the US and Russia are starting to destroy their atomic bombs but it is not good enough. They need to stop reducing their arsenal of weapons and eliminate them completely. Opponents of this idea claim that owning arnaments like atomic bombs mutually assures governments that they both have the potential for ultimate destruction. But is that really a good or virtuous thing? People who appear to be psychopaths  run a number of countries. For instance take the ruler of Zimbabwe: Robert Mugabe. He is at the potentially senile age of 89. His mind is failing. Can you begin to comprehend what would happen if he got his hands on an atomic bomb? The result would be anarchy. Or take the ruler of Syria, President Assad. He has already murdered masses of people by chemical gas attack and has publicly stated that he would destroy the state of Israel. For rulers like these men to possess weapons with such a huge destructive potential is a simply ludicrous thought. If some unhinged individual were to drop an atomic bomb now it would result in retaliation and possibly the biggest global catastrophe this planet has ever seen. We need to think about the consequences. It is a statement of fact that the more of something being produced the easier it is to acquire. Yes, this can concern nuclear weapons also. When more nuclear warheads are being manufactured there is a bigger chance of them being stolen or worse being detonated. Therefore, there is a much larger risk of them falling into the wrong hands. According to the International Atomic Energy Agency, there have been 18 cases of loss but most likely theft of uranium and plutonium. These elements are key when constructing a bomb. To make matters worse, there have been 11 whole nuclear bombs lost in the United States. They have never been recovered. If agencies and governments are finding it hard to keep track of their materials now, think of how impossible it would be if every country had their own arsenal of nuclear weapons? If these lost bombs are in the hands of terrorists at present I can guarantee that they will currently be considering how best to us e them to maximise their effect. To conclude, the fact is that if every country were to have the right to possess nuclear weapons we would all be living in constant fear of attack. Our lives would be very different; we would be insecure with regards to our safety and this would impact greatly on how we lived our lives – we would need to be significantly more vigilant. A small example of this is the potential effect that liquid explosives has on air travel where we can’t take any fluids that are more than 100ml into an airport. That is just for liquid explosives, what limits would be required to ensure nuclear components weren’t being smuggled? If one country were to drop a bomb it would set off a chain reaction, all it would take is for one rogue state or  organisation to detonate a bomb and the world would effectively end through nuclear Armageddon. BIBLIOGRAPHY http://nonukes.org/cd18_sixarg.htm http://www.abolishnukes.com/short_essays/ten_reasons_krieger.html http://www.debate.org/opinions/should-nuclear-weapons-be-abolished http://debatewise.org/debates/144-eliminate-all-nuclear-weapons/